Serine proteases, their inhibitors and allergy
نویسندگان
چکیده
منابع مشابه
Epidermal Serine Proteases and Their Inhibitors in Atopic Dermatitis
The skin and its appendages protect the body from water loss, chemical and physical damages, UV-radiation and infection by pathogenic as well as non-pathogenic microbes. The protective function of both, the physical and the chemical barrier, is provided from epidermal keratinocytes, which are continuously dividing in the stratum basale and differentiating towards the surface (Candi et al. 2005)...
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Proteases are not merely restricted to digestive purposes and remodeling of extracellular matrix and tissues, but are also key factors for the induction of physiological immune responses. This induction can be direct, through the degradation of pathogens within phagolysosomes, or indirect, through the activation of key pattern recognition receptors (PRRs), such as toll-like receptors (TLRs). Un...
متن کاملSerine proteases, inhibitors and receptors in renal fibrosis.
Chronic kidney disease (CKD) is estimated to affect one in eight adults. Their kidney function progressively deteriorates as inflammatory and fibrotic processes damage nephrons. New therapies to prevent renal functional decline must build on basic research studies that identify critical cellular and molecular mediators. Plasminogen activator inhibitor-1 (PAI-1), a potent fibrosis-promoting glyc...
متن کاملNeutrophil serine proteases and their endogenous inhibitors in coronary artery ectasia patients
OBJECTIVE Proteolytic enzymes possibly contribute to coronary artery ectasia (CAE). This study aimed to determine whether neutrophils, neutrophil serine proteases (NSPs), and their endogenous inhibitors participated in the pathological process of CAE. METHODS The study consisted of 30 patients with CAE, 30 patients with coronary artery disease (CAD), and 29 subjects with normal coronary arter...
متن کاملIrreversible inhibitors of serine, cysteine, and threonine proteases.
F. Vinyl Sulfones and Other Michael Acceptors 4683 G. Azodicarboxamides 4695 IV. Acylating Agents 4695 A. Aza-peptides 4695 B. Carbamates 4699 C. Peptidyl Acyl Hydroxamates 4700 D. â-Lactams and Related Inhibitors 4704 E. Heterocyclic Inhibitors 4714 1. Isocoumarins 4715 2. Benzoxazinones 4722 3. Saccharins 4725 4. Miscellaneous Heterocyclic Inhibitors 4728 V. Phosphonylation Agents 4728 A. Pep...
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ژورنال
عنوان ژورنال: Allergy
سال: 2006
ISSN: 0105-4538,1398-9995
DOI: 10.1111/j.1398-9995.2006.01233.x